Disorder Of laboratory parameters in hospitalized patients during Covid-19 infection

Background. The coronavirus disease (COVID-19) is an infectious disease caused by the SARS-CoV-2 virus. A disturbance in the number of white blood cells results from direct damage to cells, primarily lymphocytes, by the SARS-CoV-2 virus.

Aim. The work aims to examine the impact of the SARS-CoV-2 virus on the laboratory parameter values ​​in bedridden patients during hospitalization.

Results. To determine the impact of COVID-19 infection on laboratory parameter values ​​, the study included 80 respondents hospitalized at the UCC Tuzla Infectious Diseases Clinic from 1.1.2021. - 31.12.2021. year. Among the respondents, 58.75% were men and 41.25% were women. A review of laboratory findings shows that there is a statistically significant difference between erythrocyte values ​​and the time of measurement (P=0.028). At admission, 93.75% of subjects had high C-reactive protein (CRP) values, 87.50% of subjects on day 5 of measurement, and 67.50% of subjects had high values ​​at discharge from the hospital. There was a statistically significant increase in CRP values ​​compared to reference values ​​(P=0.000). There was a statistically significant increase in platelets in subjects measured on admission (11.25% of subjects), on the 5th day of hospital stay (28.75% of subjects), and at discharge (33.75% of subjects) (P=0.000).

Conclusion. Given the results obtained, we can conclude about the impact of the SARS-CoV-2 virus on the disruption of laboratory parameter values, especially the decrease in the number of erythrocytes and the increase in ferritin and C-reactive protein.