Effect of autoantibodies and cytokines on thyroid disorders in Thi-Qar

Introduction: The thyroid gland is one of the important endocrine gland that have many functional activates  in the body. It is usually located in the front of the neck and is shaped like a butterfly. It goes all the way down to the platysma, stern thyroid, and Stern hyoid muscles. In all vertebrates, the thyroid gland and its hormones perform several important activities.

Methodology: Fifty patients diagnosed with hyperthyroidism disease (25 males and 25 females). 50 subjects in good health as controls (25 males and 25 females).

Results and dissuasion: When compared to controls, the findings of our investigation (17.04 ± 5.10 vs. 1.15 ±0.25 U /l) demonstrate a substantial rise (P≥0.00) of TSH-receptor Ab levels in the subjects (17.04 ± 5.10 vs. 1.15 ±0.25 U/l). The findings revealed a substantial rise (P≥0.00) in FT4 level in subjects (6.16 ±0.62 vs. 1.40±0.24 ng/dl) compared to controls. In our investigation, the T3 level demonstrates a considerable rise (P≥0.00) of patients (2.81±0.20 vs. 0.32±0.07 ng/dl) vs. control. The findings of our investigation, which were presented in table 3.2, clearly demonstrated a substantial drop (P≥0.00) of TSH level in subjects was (0.19± 00.6 vs. 3.19± 0.53 IU/L) compared to controls.

Conclusions: TSH-R Ab is the better hyperthyroidism marker, especially in individuals having elevated TNF plus IL-6, in both males as well as females. The close relationship among TSH-R Ab elevation, FT-4 as well as FT-3 concentration in patients having hyperthyroidisms, which is associated with increased immune response activity manifested in TNF and IL-6 accompanied by a decrease in the concentration of TSH in general comparisons and between males and females as a control group.