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Research and review articles are invited for publication in September - October 2026 (Volume 18, Issue 1) Submit manuscript

Development and validation of UV spectroscopic method for the quantification of bempedoic acid in bulk and marketed product

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  • Development and validation of UV spectroscopic method for the quantification of bempedoic acid in bulk and marketed product

J Kushal, Manu Y 1, Anand Kumar Y 2, *, Srinivasulu N 1, Madhusri C 1 and Keerthana Shetty 1

1 Department of Pharmaceutical Chemistry, V.L College of Pharmacy, Raichur, Karnataka, India.
2 Department of Pharmaceutics, V.L College of Pharmacy, Raichur, Karnataka, India.
Research Article
Magna Scientia Advanced Research and Reviews, 2025, 13(01), 060-068
Article DOI: 10.30574/msarr.2025.13.1.0013
DOI url: https://doi.org/10.30574/msarr.2025.13.1.0013
Received on 26 November 2024; revised on 06 January 2025; accepted on 09 January 2025
Simple, rapid and precise UV spectroscopic method using two solvent blends such as Methanol: Distilled water 3:1 (DW) and Acetonitrile: Distilled water 3:2 (DW) were developed for the estimation of Bempedoic acid in bulk and marketed tablets as per ICH guidelines. The two proposed solvent blends validated for linearity, accuracy, precision, robustness, ruggedness and solution stability. The percent recoveries in the marketed tablet formulations were found to be good agreement with the label claim. The UV method validated statistically and the results suggest proposed solvent blends can employed for the routine analysis of Bempedoic acid in bulk and marketed tablet formulations.
Bempedoic acid; UV spectroscopy; Validation; Accuracy; Precision
https://msarr.magnascientiapub.com/sites/default/files/fulltext_pdf/MSARR-2025-…

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J Kushal, Manu Y, Anand Kumar Y, Srinivasulu N, Madhusri C and Keerthana Shetty. Development and validation of UV spectroscopic method for the quantification of bempedoic acid in bulk and marketed product. Magna Scientia Advanced Research and Reviews, 2025, 13(1), 060-068. Article DOI: https://doi.org/10.30574/msarr.2025.13.1.0013

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