Development and validation of simple, precise UV spectroscopic method for the estimation of valsartan in bulk and marketed tablet

Two new simple and accurate solvent blends have been presented for the estimation of Valsartan (VAL) in bulk and its tablet dosage form. The developed analytical method was validated and established in ICH Q2 (R1). Valsartan exhibit 250 nm and 251 nm for Solvent A, Solvent B respectively and found was linear for a range of 1 µg/ml – 50 µg/ml. The goodness of fit study suggests good correlation coefficient R² - 0.9998 and 0.9985 for proposed solvent blends. The validity of Beer’s law with intercept response < 2% calculated by the least square method indicating functional linearity between the concentration of analyte and the absorbance. The (LOD) and limit of quantification (LOQ) of Valsartan was within the quantifiable with % RSD < 2. The analytical method validation of proposed solvent blends was performed by carrying out precision and accuracy studies. The Accuracy percentage recovery on three different levels i.e. 50%, 100% and 150% was found to be within the acceptable limits with % RSD < 2. The proposed solvent blends were validated for specificity, precision, ruggedness, accuracy and robustness. Overall study suggest that the proposed solvent blends can be used for estimation of Valsartan in bulk and its tablet dosage form and can be applied for the everyday quality control analysis.